Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis.
Identifieur interne : 000E25 ( Main/Exploration ); précédent : 000E24; suivant : 000E26Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis.
Auteurs : Jack P. Wang [République populaire de Chine, États-Unis] ; Megan L. Matthews [États-Unis] ; Cranos M. Williams [États-Unis] ; Rui Shi [États-Unis] ; Chenmin Yang [États-Unis] ; Sermsawat Tunlaya-Anukit [États-Unis] ; Hsi-Chuan Chen [États-Unis] ; Quanzi Li [République populaire de Chine] ; Jie Liu [États-Unis] ; Chien-Yuan Lin [États-Unis] ; Punith Naik [États-Unis] ; Ying-Hsuan Sun [Taïwan] ; Philip L. Loziuk [États-Unis] ; Ting-Feng Yeh [Taïwan] ; Hoon Kim [États-Unis] ; Erica Gjersing [États-Unis] ; Todd Shollenberger [États-Unis] ; Christopher M. Shuford [États-Unis] ; Jina Song [États-Unis] ; Zachary Miller [États-Unis] ; Yung-Yun Huang [États-Unis] ; Charles W. Edmunds [États-Unis] ; Baoguang Liu [République populaire de Chine] ; Yi Sun [République populaire de Chine] ; Ying-Chung Jimmy Lin [République populaire de Chine, États-Unis, Taïwan] ; Wei Li [République populaire de Chine, États-Unis] ; Hao Chen [États-Unis] ; Ilona Peszlen [États-Unis] ; Joel J. Ducoste [États-Unis] ; John Ralph [États-Unis] ; Hou-Min Chang [États-Unis] ; David C. Muddiman [États-Unis] ; Mark F. Davis [États-Unis] ; Chris Smith [États-Unis] ; Fikret Isik [États-Unis] ; Ronald Sederoff [États-Unis] ; Vincent L. Chiang [République populaire de Chine, États-Unis]Source :
- Nature communications [ 2041-1723 ] ; 2018.
Descripteurs français
- KwdFr :
- Arbres (génétique), Arbres (métabolisme), Bois (composition chimique), Bois (physiologie), Lignine (biosynthèse), Lignine (génétique), Populus (génétique), Populus (métabolisme), Régulation de l'expression des gènes végétaux (MeSH), Transcriptome (génétique), Végétaux génétiquement modifiés (génétique), Xylème (métabolisme).
- MESH :
- biosynthèse : Lignine.
- composition chimique : Bois.
- génétique : Arbres, Lignine, Populus, Transcriptome, Végétaux génétiquement modifiés.
- métabolisme : Arbres, Populus, Xylème.
- physiologie : Bois.
- Régulation de l'expression des gènes végétaux.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Lignin.
- chemical , genetics : Lignin.
- chemistry : Wood.
- genetics : Plants, Genetically Modified, Populus, Transcriptome, Trees.
- metabolism : Populus, Trees, Xylem.
- physiology : Wood.
- Gene Expression Regulation, Plant.
Abstract
A multi-omics quantitative integrative analysis of lignin biosynthesis can advance the strategic engineering of wood for timber, pulp, and biofuels. Lignin is polymerized from three monomers (monolignols) produced by a grid-like pathway. The pathway in wood formation of Populus trichocarpa has at least 21 genes, encoding enzymes that mediate 37 reactions on 24 metabolites, leading to lignin and affecting wood properties. We perturb these 21 pathway genes and integrate transcriptomic, proteomic, fluxomic and phenomic data from 221 lines selected from ~2000 transgenics (6-month-old). The integrative analysis estimates how changing expression of pathway gene or gene combination affects protein abundance, metabolic-flux, metabolite concentrations, and 25 wood traits, including lignin, tree-growth, density, strength, and saccharification. The analysis then predicts improvements in any of these 25 traits individually or in combinations, through engineering expression of specific monolignol genes. The analysis may lead to greater understanding of other pathways for improved growth and adaptation.
DOI: 10.1038/s41467-018-03863-z
PubMed: 29679008
PubMed Central: PMC5910405
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hsi Chuan" sort="Chen, Hsi Chuan" uniqKey="Chen H" first="Hsi-Chuan" last="Chen">Hsi-Chuan Chen</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Li, Quanzi" sort="Li, Quanzi" uniqKey="Li Q" first="Quanzi" last="Li">Quanzi Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, 100091, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, 100091</wicri:regionArea><wicri:noRegion>100091</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jie" sort="Liu, Jie" uniqKey="Liu J" first="Jie" last="Liu">Jie Liu</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chien Yuan" sort="Lin, Chien Yuan" uniqKey="Lin C" first="Chien-Yuan" last="Lin">Chien-Yuan Lin</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608</wicri:regionArea><wicri:noRegion>94608</wicri:noRegion></affiliation></author><author><name sortKey="Naik, Punith" sort="Naik, Punith" uniqKey="Naik P" first="Punith" last="Naik">Punith Naik</name><affiliation wicri:level="1"><nlm:affiliation>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Ying Hsuan" sort="Sun, Ying Hsuan" uniqKey="Sun Y" first="Ying-Hsuan" last="Sun">Ying-Hsuan Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forestry, National Chung-Hsing University, Taichung, 40227, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Forestry, National Chung-Hsing University, Taichung, 40227</wicri:regionArea><wicri:noRegion>40227</wicri:noRegion></affiliation></author><author><name sortKey="Loziuk, Philip L" sort="Loziuk, Philip L" uniqKey="Loziuk P" first="Philip L" last="Loziuk">Philip L. Loziuk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Yeh, Ting Feng" sort="Yeh, Ting Feng" uniqKey="Yeh T" first="Ting-Feng" last="Yeh">Ting-Feng Yeh</name><affiliation wicri:level="1"><nlm:affiliation>School of Forestry and Resource Conservation, National Taiwan University, Taipei, 10617, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Forestry and Resource Conservation, National Taiwan University, Taipei, 10617</wicri:regionArea><wicri:noRegion>10617</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hoon" sort="Kim, Hoon" uniqKey="Kim H" first="Hoon" last="Kim">Hoon Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726</wicri:regionArea><wicri:noRegion>53726</wicri:noRegion></affiliation></author><author><name sortKey="Gjersing, Erica" sort="Gjersing, Erica" uniqKey="Gjersing E" first="Erica" last="Gjersing">Erica Gjersing</name><affiliation wicri:level="1"><nlm:affiliation>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401</wicri:regionArea><wicri:noRegion>80401</wicri:noRegion></affiliation></author><author><name sortKey="Shollenberger, Todd" sort="Shollenberger, Todd" uniqKey="Shollenberger T" first="Todd" last="Shollenberger">Todd Shollenberger</name><affiliation wicri:level="1"><nlm:affiliation>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401</wicri:regionArea><wicri:noRegion>80401</wicri:noRegion></affiliation></author><author><name sortKey="Shuford, Christopher M" sort="Shuford, Christopher M" uniqKey="Shuford C" first="Christopher M" last="Shuford">Christopher M. Shuford</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Song, Jina" sort="Song, Jina" uniqKey="Song J" first="Jina" last="Song">Jina Song</name><affiliation wicri:level="1"><nlm:affiliation>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Zachary" sort="Miller, Zachary" uniqKey="Miller Z" first="Zachary" last="Miller">Zachary Miller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yung Yun" sort="Huang, Yung Yun" uniqKey="Huang Y" first="Yung-Yun" last="Huang">Yung-Yun Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Operations Research, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Operations Research, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Edmunds, Charles W" sort="Edmunds, Charles W" uniqKey="Edmunds C" first="Charles W" last="Edmunds">Charles W. Edmunds</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Baoguang" sort="Liu, Baoguang" uniqKey="Liu B" first="Baoguang" last="Liu">Baoguang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forestry, Beihua University, Jilin, 132013, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forestry, Beihua University, Jilin, 132013</wicri:regionArea><wicri:noRegion>132013</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yi" sort="Sun, Yi" uniqKey="Sun Y" first="Yi" last="Sun">Yi Sun</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ying Chung Jimmy" sort="Lin, Ying Chung Jimmy" uniqKey="Lin Y" first="Ying-Chung Jimmy" last="Lin">Ying-Chung Jimmy Lin</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, College of Life Science, National Taiwan University, Taipei, 10617, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, College of Life Science, National Taiwan University, Taipei, 10617</wicri:regionArea><wicri:noRegion>10617</wicri:noRegion></affiliation></author><author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Peszlen, Ilona" sort="Peszlen, Ilona" uniqKey="Peszlen I" first="Ilona" last="Peszlen">Ilona Peszlen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Ducoste, Joel J" sort="Ducoste, Joel J" uniqKey="Ducoste J" first="Joel J" last="Ducoste">Joel J. Ducoste</name><affiliation wicri:level="1"><nlm:affiliation>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Ralph, John" sort="Ralph, John" uniqKey="Ralph J" first="John" last="Ralph">John Ralph</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726</wicri:regionArea><wicri:noRegion>53726</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hou Min" sort="Chang, Hou Min" uniqKey="Chang H" first="Hou-Min" last="Chang">Hou-Min Chang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Muddiman, David C" sort="Muddiman, David C" uniqKey="Muddiman D" first="David C" last="Muddiman">David C. Muddiman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Davis, Mark F" sort="Davis, Mark F" uniqKey="Davis M" first="Mark F" last="Davis">Mark F. Davis</name><affiliation wicri:level="1"><nlm:affiliation>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608</wicri:regionArea><wicri:noRegion>94608</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Chris" sort="Smith, Chris" uniqKey="Smith C" first="Chris" last="Smith">Chris Smith</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Isik, Fikret" sort="Isik, Fikret" uniqKey="Isik F" first="Fikret" last="Isik">Fikret Isik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Sederoff, Ronald" sort="Sederoff, Ronald" uniqKey="Sederoff R" first="Ronald" last="Sederoff">Ronald Sederoff</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Chiang, Vincent L" sort="Chiang, Vincent L" uniqKey="Chiang V" first="Vincent L" last="Chiang">Vincent L. Chiang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China. vchiang@ncsu.edu.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA. vchiang@ncsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA. vchiang@ncsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29679008</idno><idno type="pmid">29679008</idno><idno type="doi">10.1038/s41467-018-03863-z</idno><idno type="pmc">PMC5910405</idno><idno type="wicri:Area/Main/Corpus">000E75</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000E75</idno><idno type="wicri:Area/Main/Curation">000E75</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000E75</idno><idno type="wicri:Area/Main/Exploration">000E75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis.</title><author><name sortKey="Wang, Jack P" sort="Wang, Jack P" uniqKey="Wang J" first="Jack P" last="Wang">Jack P. Wang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Matthews, Megan L" sort="Matthews, Megan L" uniqKey="Matthews M" first="Megan L" last="Matthews">Megan L. Matthews</name><affiliation wicri:level="1"><nlm:affiliation>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Williams, Cranos M" sort="Williams, Cranos M" uniqKey="Williams C" first="Cranos M" last="Williams">Cranos M. Williams</name><affiliation wicri:level="1"><nlm:affiliation>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Rui" sort="Shi, Rui" uniqKey="Shi R" first="Rui" last="Shi">Rui Shi</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Chenmin" sort="Yang, Chenmin" uniqKey="Yang C" first="Chenmin" last="Yang">Chenmin Yang</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Tunlaya Anukit, Sermsawat" sort="Tunlaya Anukit, Sermsawat" uniqKey="Tunlaya Anukit S" first="Sermsawat" last="Tunlaya-Anukit">Sermsawat Tunlaya-Anukit</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hsi Chuan" sort="Chen, Hsi Chuan" uniqKey="Chen H" first="Hsi-Chuan" last="Chen">Hsi-Chuan Chen</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Li, Quanzi" sort="Li, Quanzi" uniqKey="Li Q" first="Quanzi" last="Li">Quanzi Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, 100091, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, 100091</wicri:regionArea><wicri:noRegion>100091</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Jie" sort="Liu, Jie" uniqKey="Liu J" first="Jie" last="Liu">Jie Liu</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Chien Yuan" sort="Lin, Chien Yuan" uniqKey="Lin C" first="Chien-Yuan" last="Lin">Chien-Yuan Lin</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608</wicri:regionArea><wicri:noRegion>94608</wicri:noRegion></affiliation></author><author><name sortKey="Naik, Punith" sort="Naik, Punith" uniqKey="Naik P" first="Punith" last="Naik">Punith Naik</name><affiliation wicri:level="1"><nlm:affiliation>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Ying Hsuan" sort="Sun, Ying Hsuan" uniqKey="Sun Y" first="Ying-Hsuan" last="Sun">Ying-Hsuan Sun</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forestry, National Chung-Hsing University, Taichung, 40227, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Forestry, National Chung-Hsing University, Taichung, 40227</wicri:regionArea><wicri:noRegion>40227</wicri:noRegion></affiliation></author><author><name sortKey="Loziuk, Philip L" sort="Loziuk, Philip L" uniqKey="Loziuk P" first="Philip L" last="Loziuk">Philip L. Loziuk</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Yeh, Ting Feng" sort="Yeh, Ting Feng" uniqKey="Yeh T" first="Ting-Feng" last="Yeh">Ting-Feng Yeh</name><affiliation wicri:level="1"><nlm:affiliation>School of Forestry and Resource Conservation, National Taiwan University, Taipei, 10617, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Forestry and Resource Conservation, National Taiwan University, Taipei, 10617</wicri:regionArea><wicri:noRegion>10617</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Hoon" sort="Kim, Hoon" uniqKey="Kim H" first="Hoon" last="Kim">Hoon Kim</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726</wicri:regionArea><wicri:noRegion>53726</wicri:noRegion></affiliation></author><author><name sortKey="Gjersing, Erica" sort="Gjersing, Erica" uniqKey="Gjersing E" first="Erica" last="Gjersing">Erica Gjersing</name><affiliation wicri:level="1"><nlm:affiliation>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401</wicri:regionArea><wicri:noRegion>80401</wicri:noRegion></affiliation></author><author><name sortKey="Shollenberger, Todd" sort="Shollenberger, Todd" uniqKey="Shollenberger T" first="Todd" last="Shollenberger">Todd Shollenberger</name><affiliation wicri:level="1"><nlm:affiliation>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401</wicri:regionArea><wicri:noRegion>80401</wicri:noRegion></affiliation></author><author><name sortKey="Shuford, Christopher M" sort="Shuford, Christopher M" uniqKey="Shuford C" first="Christopher M" last="Shuford">Christopher M. Shuford</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Song, Jina" sort="Song, Jina" uniqKey="Song J" first="Jina" last="Song">Jina Song</name><affiliation wicri:level="1"><nlm:affiliation>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Miller, Zachary" sort="Miller, Zachary" uniqKey="Miller Z" first="Zachary" last="Miller">Zachary Miller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Yung Yun" sort="Huang, Yung Yun" uniqKey="Huang Y" first="Yung-Yun" last="Huang">Yung-Yun Huang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Operations Research, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Operations Research, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Edmunds, Charles W" sort="Edmunds, Charles W" uniqKey="Edmunds C" first="Charles W" last="Edmunds">Charles W. Edmunds</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Baoguang" sort="Liu, Baoguang" uniqKey="Liu B" first="Baoguang" last="Liu">Baoguang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forestry, Beihua University, Jilin, 132013, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Forestry, Beihua University, Jilin, 132013</wicri:regionArea><wicri:noRegion>132013</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Yi" sort="Sun, Yi" uniqKey="Sun Y" first="Yi" last="Sun">Yi Sun</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ying Chung Jimmy" sort="Lin, Ying Chung Jimmy" uniqKey="Lin Y" first="Ying-Chung Jimmy" last="Lin">Ying-Chung Jimmy Lin</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Life Sciences, College of Life Science, National Taiwan University, Taipei, 10617, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Life Sciences, College of Life Science, National Taiwan University, Taipei, 10617</wicri:regionArea><wicri:noRegion>10617</wicri:noRegion></affiliation></author><author><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Peszlen, Ilona" sort="Peszlen, Ilona" uniqKey="Peszlen I" first="Ilona" last="Peszlen">Ilona Peszlen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Ducoste, Joel J" sort="Ducoste, Joel J" uniqKey="Ducoste J" first="Joel J" last="Ducoste">Joel J. Ducoste</name><affiliation wicri:level="1"><nlm:affiliation>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Ralph, John" sort="Ralph, John" uniqKey="Ralph J" first="John" last="Ralph">John Ralph</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726</wicri:regionArea><wicri:noRegion>53726</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hou Min" sort="Chang, Hou Min" uniqKey="Chang H" first="Hou-Min" last="Chang">Hou-Min Chang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Muddiman, David C" sort="Muddiman, David C" uniqKey="Muddiman D" first="David C" last="Muddiman">David C. Muddiman</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Davis, Mark F" sort="Davis, Mark F" uniqKey="Davis M" first="Mark F" last="Davis">Mark F. Davis</name><affiliation wicri:level="1"><nlm:affiliation>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608</wicri:regionArea><wicri:noRegion>94608</wicri:noRegion></affiliation></author><author><name sortKey="Smith, Chris" sort="Smith, Chris" uniqKey="Smith C" first="Chris" last="Smith">Chris Smith</name><affiliation wicri:level="1"><nlm:affiliation>Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Isik, Fikret" sort="Isik, Fikret" uniqKey="Isik F" first="Fikret" last="Isik">Fikret Isik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Sederoff, Ronald" sort="Sederoff, Ronald" uniqKey="Sederoff R" first="Ronald" last="Sederoff">Ronald Sederoff</name><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author><author><name sortKey="Chiang, Vincent L" sort="Chiang, Vincent L" uniqKey="Chiang V" first="Vincent L" last="Chiang">Vincent L. Chiang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China. vchiang@ncsu.edu.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040</wicri:regionArea><wicri:noRegion>150040</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA. vchiang@ncsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA. vchiang@ncsu.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695</wicri:regionArea><wicri:noRegion>27695</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gene Expression Regulation, Plant (MeSH)</term><term>Lignin (biosynthesis)</term><term>Lignin (genetics)</term><term>Plants, Genetically Modified (genetics)</term><term>Populus (genetics)</term><term>Populus (metabolism)</term><term>Transcriptome (genetics)</term><term>Trees (genetics)</term><term>Trees (metabolism)</term><term>Wood (chemistry)</term><term>Wood (physiology)</term><term>Xylem (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Arbres (génétique)</term><term>Arbres (métabolisme)</term><term>Bois (composition chimique)</term><term>Bois (physiologie)</term><term>Lignine (biosynthèse)</term><term>Lignine (génétique)</term><term>Populus (génétique)</term><term>Populus (métabolisme)</term><term>Régulation de l'expression des gènes végétaux (MeSH)</term><term>Transcriptome (génétique)</term><term>Végétaux génétiquement modifiés (génétique)</term><term>Xylème (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Lignin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Lignin</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Lignine</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Wood</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Bois</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plants, Genetically Modified</term><term>Populus</term><term>Transcriptome</term><term>Trees</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Arbres</term><term>Lignine</term><term>Populus</term><term>Transcriptome</term><term>Végétaux génétiquement modifiés</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Populus</term><term>Trees</term><term>Xylem</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Arbres</term><term>Populus</term><term>Xylème</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Bois</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Wood</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Gene Expression Regulation, Plant</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Régulation de l'expression des gènes végétaux</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A multi-omics quantitative integrative analysis of lignin biosynthesis can advance the strategic engineering of wood for timber, pulp, and biofuels. Lignin is polymerized from three monomers (monolignols) produced by a grid-like pathway. The pathway in wood formation of Populus trichocarpa has at least 21 genes, encoding enzymes that mediate 37 reactions on 24 metabolites, leading to lignin and affecting wood properties. We perturb these 21 pathway genes and integrate transcriptomic, proteomic, fluxomic and phenomic data from 221 lines selected from ~2000 transgenics (6-month-old). The integrative analysis estimates how changing expression of pathway gene or gene combination affects protein abundance, metabolic-flux, metabolite concentrations, and 25 wood traits, including lignin, tree-growth, density, strength, and saccharification. The analysis then predicts improvements in any of these 25 traits individually or in combinations, through engineering expression of specific monolignol genes. The analysis may lead to greater understanding of other pathways for improved growth and adaptation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29679008</PMID><DateCompleted><Year>2018</Year><Month>12</Month><Day>11</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>04</Month><Day>20</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis.</ArticleTitle><Pagination><MedlinePgn>1579</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41467-018-03863-z</ELocationID><Abstract><AbstractText>A multi-omics quantitative integrative analysis of lignin biosynthesis can advance the strategic engineering of wood for timber, pulp, and biofuels. Lignin is polymerized from three monomers (monolignols) produced by a grid-like pathway. The pathway in wood formation of Populus trichocarpa has at least 21 genes, encoding enzymes that mediate 37 reactions on 24 metabolites, leading to lignin and affecting wood properties. We perturb these 21 pathway genes and integrate transcriptomic, proteomic, fluxomic and phenomic data from 221 lines selected from ~2000 transgenics (6-month-old). The integrative analysis estimates how changing expression of pathway gene or gene combination affects protein abundance, metabolic-flux, metabolite concentrations, and 25 wood traits, including lignin, tree-growth, density, strength, and saccharification. The analysis then predicts improvements in any of these 25 traits individually or in combinations, through engineering expression of specific monolignol genes. The analysis may lead to greater understanding of other pathways for improved growth and adaptation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jack P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matthews</LastName><ForeName>Megan L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Williams</LastName><ForeName>Cranos M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Rui</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Chenmin</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tunlaya-Anukit</LastName><ForeName>Sermsawat</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Hsi-Chuan</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Quanzi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Tree Genetics and Breeding, Chinese Academy of Forestry, Beijing, 100091, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Chien-Yuan</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Naik</LastName><ForeName>Punith</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Ying-Hsuan</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Forestry, National Chung-Hsing University, Taichung, 40227, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Loziuk</LastName><ForeName>Philip L</ForeName><Initials>PL</Initials><AffiliationInfo><Affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeh</LastName><ForeName>Ting-Feng</ForeName><Initials>TF</Initials><AffiliationInfo><Affiliation>School of Forestry and Resource Conservation, National Taiwan University, Taipei, 10617, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Hoon</ForeName><Initials>H</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7425-7464</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gjersing</LastName><ForeName>Erica</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shollenberger</LastName><ForeName>Todd</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shuford</LastName><ForeName>Christopher M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Jina</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-9931-1129</Identifier><AffiliationInfo><Affiliation>Electrical and Computer Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miller</LastName><ForeName>Zachary</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yung-Yun</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Department of Operations Research, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edmunds</LastName><ForeName>Charles W</ForeName><Initials>CW</Initials><AffiliationInfo><Affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Baoguang</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Forestry, Beihua University, Jilin, 132013, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Ying-Chung Jimmy</ForeName><Initials>YJ</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Life Sciences, College of Life Science, National Taiwan University, Taipei, 10617, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Hao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peszlen</LastName><ForeName>Ilona</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ducoste</LastName><ForeName>Joel J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Civil, Construction and Environmental Engineering, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ralph</LastName><ForeName>John</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6093-4521</Identifier><AffiliationInfo><Affiliation>Department of Biochemistry, and the DOE Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Hou-Min</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muddiman</LastName><ForeName>David C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Department of Chemistry, W.M. Keck Fourier Transform Mass Spectrometry Laboratory, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>Mark F</ForeName><Initials>MF</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-4541-9852</Identifier><AffiliationInfo><Affiliation>Joint BioEnergy Institute, Lawrence Berkeley National Laboratory, Emeryville, CA, 94608, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Bioinformatics Research Center, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isik</LastName><ForeName>Fikret</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sederoff</LastName><ForeName>Ronald</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chiang</LastName><ForeName>Vincent L</ForeName><Initials>VL</Initials><AffiliationInfo><Affiliation>State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin, 150040, China. vchiang@ncsu.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Forest Biotechnology Group, Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC, 27695, USA. vchiang@ncsu.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Forest Biomaterials, North Carolina State University, Raleigh, NC, 27695, USA. vchiang@ncsu.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>04</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9005-53-2</RegistryNumber><NameOfSubstance UI="D008031">Lignin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D018506" MajorTopicYN="N">Gene Expression Regulation, Plant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008031" MajorTopicYN="N">Lignin</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059467" MajorTopicYN="N">Transcriptome</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014197" MajorTopicYN="N">Trees</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014934" MajorTopicYN="N">Wood</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D052584" MajorTopicYN="N">Xylem</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>07</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>03</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>4</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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Wang</name></noRegion><name sortKey="Chiang, Vincent L" sort="Chiang, Vincent L" uniqKey="Chiang V" first="Vincent L" last="Chiang">Vincent L. Chiang</name><name sortKey="Li, Quanzi" sort="Li, Quanzi" uniqKey="Li Q" first="Quanzi" last="Li">Quanzi Li</name><name sortKey="Li, Wei" sort="Li, Wei" uniqKey="Li W" first="Wei" last="Li">Wei Li</name><name sortKey="Lin, Ying Chung Jimmy" sort="Lin, Ying Chung Jimmy" uniqKey="Lin Y" first="Ying-Chung Jimmy" last="Lin">Ying-Chung Jimmy Lin</name><name sortKey="Liu, Baoguang" sort="Liu, Baoguang" uniqKey="Liu B" first="Baoguang" last="Liu">Baoguang Liu</name><name sortKey="Sun, Yi" sort="Sun, Yi" uniqKey="Sun Y" first="Yi" last="Sun">Yi Sun</name></country><country name="États-Unis"><noRegion><name sortKey="Wang, Jack P" sort="Wang, Jack P" uniqKey="Wang J" first="Jack P" last="Wang">Jack P. Wang</name></noRegion><name sortKey="Chang, Hou Min" sort="Chang, Hou Min" uniqKey="Chang H" first="Hou-Min" last="Chang">Hou-Min Chang</name><name sortKey="Chen, Hao" sort="Chen, Hao" uniqKey="Chen H" first="Hao" last="Chen">Hao Chen</name><name sortKey="Chen, Hsi Chuan" sort="Chen, Hsi Chuan" uniqKey="Chen H" first="Hsi-Chuan" last="Chen">Hsi-Chuan Chen</name><name sortKey="Chiang, Vincent L" sort="Chiang, Vincent L" uniqKey="Chiang V" first="Vincent L" last="Chiang">Vincent L. Chiang</name><name sortKey="Chiang, Vincent L" sort="Chiang, Vincent L" uniqKey="Chiang V" first="Vincent L" last="Chiang">Vincent L. Chiang</name><name sortKey="Davis, Mark F" sort="Davis, Mark F" uniqKey="Davis M" first="Mark F" last="Davis">Mark F. Davis</name><name sortKey="Ducoste, Joel J" sort="Ducoste, Joel J" uniqKey="Ducoste J" first="Joel J" last="Ducoste">Joel J. 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Williams</name><name sortKey="Yang, Chenmin" sort="Yang, Chenmin" uniqKey="Yang C" first="Chenmin" last="Yang">Chenmin Yang</name></country><country name="Taïwan"><noRegion><name sortKey="Sun, Ying Hsuan" sort="Sun, Ying Hsuan" uniqKey="Sun Y" first="Ying-Hsuan" last="Sun">Ying-Hsuan Sun</name></noRegion><name sortKey="Lin, Ying Chung Jimmy" sort="Lin, Ying Chung Jimmy" uniqKey="Lin Y" first="Ying-Chung Jimmy" last="Lin">Ying-Chung Jimmy Lin</name><name sortKey="Yeh, Ting Feng" sort="Yeh, Ting Feng" uniqKey="Yeh T" first="Ting-Feng" last="Yeh">Ting-Feng Yeh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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